I've had this problem before. I'm not exactly sure what causes it, but rarely I'll open a dataset in the design view and only the XML markup shows. The first time this happened I made the mistake of running some Visual Studio reinstall command I found out there and lost a bunch of my personal settings. Here's the quick, painless solution:
If that doesn't work you can always try a Visual Studio repair of some sort, but remember to backup your Visual Studio settings and any Code Snippets you've tweaked.
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